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Thread: Steroids killing your leydig cells

  1. #1
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    Default Steroids killing your leydig cells

    Leydig cell death is real and can be explained.

    See here: Male Hypogonadism: Basic, Clinical, and Therapeutic Principles
    By Stephen J. Winters Page 36


    Leydig Cell Toxicology
    Several agents have been identified as Leydig cell toxicants, including ethanol, ethane 1,2 dimethanesulphonate (EDS), 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCCD), and steroid hormone receptor antagonists. These toxicants can damage Leydig cells in three ways: overstimulation or inhibition of steroidogenesis, induction of tumor formation, and promotion of cell death. Leydig cells are vulnerable to several toxins through direct actions and/or by disruption of the hypothalamic–pituitary axis. Toxicants, such as ethanol, interfere with Leydig cell steroidogenesis by interfering with LH secretion, LH receptor binding, intracellular signal transduction pathways, and steroidogenic enzyme activities. Ethanol, for example, decreases LH secretion and reduces LH receptor binding and intracellular cyclic guanosine 5′-monophosphate (GMP) levels. Hence, chronic alcohol abuse causes declines in testosterone levels (138–140). Tumor formation and cell death are also observed after toxicant exposures. Carcinogenesis is considered to be a consequence of multiple insults to the genome. Necrosis and apoptosis have both been implicated in the process of toxicant-related Leydig cell death, with ethylene dimethanesulfonate exposure as the experimental paradigm (141).
    So you can understand this a little better inhibition of steroidogenesis eg taking steroids or something else to shut down the creation of testosterone by stopping the release of LH resulting in cell damage and death. Or by disruption of the hypothalamic–pituitary axis which happens every time you take steroids by shutting down LH production.

    Chronic Effects of LH
    LH also has long-term trophic effects on Leydig cells, requiring both transcription and increased translation of proteins. Chronic stimulation by LH is required for maintenance of Leydig cell steroidogenic enzyme levels and to support the steroidogenic organelle aparatus, including mitochondrial membrane potential and SER volume. Inhibition of LH action can be achieved by hypophysectomy (91–93), suppression of gonadotropins through steroid administration (94–96), and neutralization of LH or LH-releasing hormone (GnRH) by specific antibodies (97). LH blockade eliminates the chronic effects of this hormone, causing Leydig cell atrophy and loss of cellular volume, SER, steroidogenic enzyme activities (particularly P-45017α and P-450scc), LH receptor numbers, and the ability to secrete testosterone in response to LH (91,95).

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    Default Re: Steroids killing your leydig cells

    Love it how you put these things to light mate, the very under-talked-about sides to steroid use. So many people don't appreciate the gravity of what they're doing to their health, talked to one bloke recently at tafe, only 19 and was talking about his first cycle and it having no side effects.... pffft, like anything's a free ride in this world lol.
    ZAC1983 likes this.

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    Default Re: Steroids killing your leydig cells

    Quote Originally Posted by KTMD View Post
    Love it how you put these things to light mate, the very under-talked-about sides to steroid use. So many people don't appreciate the gravity of what they're doing to their health, talked to one bloke recently at tafe, only 19 and was talking about his first cycle and it having no side effects.... pffft, like anything's a free ride in this world lol.
    Yeah i know i use to go on cycle and the justification was "I already produce testosterone im just going to have more of what i already have in me"...lol
    Little did i know about everything else, and now we have males in their early 20's going to doctors for HRT and wondering how they got their....lol
    Hope you see the other thread on here some where i posted about hyperplasia of leydig cells it has been proven there is hope for anyone running HRT you can restore and grow new leydig cells with the use of low dose HCG.


    Here it is here for you: Reversing HRT or avoiding HRT

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    Default Re: Steroids killing your leydig cells

    Im sure theres only 2 recorded deaths by steds in the world?

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    Smile Re: Steroids killing your leydig cells

    yeah bit hard to be exact as it comes up as "heart" disease usually. Now if taking massive doses of steroids doesn't do damage to the body one way or another there wouldn't be so many b'bers in their 40's who ate clean as, even did cardio at 100kg+ bodyweight (so fit and healthy as it would seem) yet have heat disease or clogged arteries. Yes yes yes ive heard of people who die in their 50-60s etc also but there is def a correlation between artificial hormones espec in mega doses and something weird going on with the heart muscle or the veins/arteries around it IMO. Like arseholes thats my opinion.
    ZAC

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    Default Re: Steroids killing your leydig cells

    good read. I no their are a lot of 10-20yr olds at my gym that are on... using stupid amounts with no plan and basically no idea

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    Default

    10 year olds at gym using gear??

    WOW!!!


    Sent from my iPhone using Tapatalk
    Dutch likes this.
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    Default Re: Steroids killing your leydig cells

    Quote Originally Posted by DREAM BIG View Post
    10 year olds at gym using gear??

    WOW!!!


    Sent from my iPhone using Tapatalk
    lol last time i saw a 10yr old at the gym was in the creche

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    Default Re: Steroids killing your leydig cells

    lol they mean that "decade" age group......... i hope?
    ZAC

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    Default Re: Steroids killing your leydig cells

    and here's two articles which are related, but also somewhat contradictory regarding testosterone and health :P

    http://www.ergo-log.com/justonetesto...injection.html
    http://www.ergo-log.com/toomuchcholesterol.html

    enjoy
    I never raped that girl! All I did was make a joke about raping her after she implied I was gonna rape her, then I made it look like I was raping her.

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